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A tlr3 ligand that exhibits potent inhibition of influenza virus replication and has strong adjuvant activity has the potential for dual applications in an influenza pandemic. Interaction of antigens and antibodies at mucosal surfaces. Antisense rna: Function and fate of duplex rna in cells of higher eukaryotes.
#Pika mouse trial
A controlled trial of a human papillomavirus type 16 vaccine. Koutsky L A, Ault K A, Wheeler C M, et al. Efficacy of a quadrivalent rhesus rotavirus-based human rotavirus vaccine aimed at preventing severe rotavirus diarrhea in infants and young children. Kapikian A Z, Hoshino Y, Chanock R M, et al. Enhancement of mucosal immunization with virus-like particles of simian immunodeficiency virus. When two strands are better than one: The mediators and modulators of the cellular responses to double-stranded rna. Synthetic double-stranded rna poly(i:C) combined with mucosal vaccine protects against influenza virus infection. Immunologic-mediated protection of trypanosoma congolense-infected mice by polyribonucleotides. Effects of different immunization protocols and adjuvant on antibody responses to inactivated sars-cov vaccine. Aetiology: Koch’s postulates fulfilled for sars virus. Immunol Rev, 170: 197–222.įouchier R A, Kuiken T, Schutten M, et al. Mucosal immunity and tolerance: Relevance to vaccine development. Infect Immun, 25(3): 831–837.Ĭzerkinsky C, Anjuere F, Mcghee J R, et al. Modified polyriboinosinic-polyribocytidylic acid complex: Sustained interferonemia and its physiological associates in humans. Protective effect of rotavirus vp6-specific iga monoclonal antibodies that lack neutralizing activity. J Virol, 76(2): 517–524.īurns J W, Siadat-Pajouh M, Krishnaney A A, et al. Cytokines as adjuvants for the induction of anti-human immunodeficiency virus peptide immunoglobulin g (igg) and iga antibodies in serum and mucosal secretions after nasal immunization. N Engl J Med, 338(20): 1405–1412.īradney C P, Sempowski G D, Liao H X, et al. The efficacy of live attenuated, cold-adapted, trivalent, intranasal influenzavirus vaccine in children.
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Tex Rep Biol Med, 41: 526–531.īelshe R B, Mendelman P M, Treanor J, et al. The effect of interferon on rabies infection of animals.
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Recognition of double-stranded rna and activation of nf-kappab by toll-like receptor 3. Overall, PIKA could be a good mucosal adjuvant candidate for inactivated SARS-CoV vaccine for use in possible future pandemic.Īlexopoulou L, Holt A C, Medzhitov R, et al. When intranasal immunization was used, PIKA was obligatorily for inducing neutralizing activity in serum as well as in mucosal sites and was correlated with both mucosal IgA and mucosal IgG response. Although intraperitoneal immunization of inactivated SARS-CoV vaccine alone could induce a certain level of neutralizing activity in serum as well as in mucosal sites, co-administration of inactivated SARS-CoV vaccine with PIKA as adjuvant could induce a much higher neutralizing activity. In the present study, we demonstrated that the intraperitoneal and intranasal co-administration of inactivated SARS-CoV vaccine together with this improved Poly (I:C) derivative induced strong anti-SARS-CoV mucosal and systemic humoral immune responses with neutralizing activity against pseudotyped virus. PIKA, a stabilized derivative of Poly (I:C), was previously reported to be safe and potent as adjuvant in mouse models. The development of a safe and effective mucosal adjuvant and vaccine for prevention of emergent infectious diseases such as SARS will be an important advancement. However, safe and potent adjuvants, especially with more efficient and economical needle-free vaccination are always needed more urgently in a pandemic. Inactivated SARS-CoV has been explored as a vaccine against SARS-CoV. Severe Acute Respiratory Syndrome (SARS) is a deadly infectious disease caused by SARS Coronavirus (SARS-CoV).
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